Switch Ser
Todays deals on Switch Ser?
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NIB Square D Float Switch HW35Z20 Ser A _ HW352Z2O _ 0313 _ 2 Pole Ratings $5,000.00 |
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NEW SQUARE D I-LINE BUSWAY SWITCH CAT,# PBQ4640 SER. 5 $1,600.00 |
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ALLEN BRADLEY 808-M1LA2 SER.F SPEED SWITCH NEW 808M1LA2 $1,319.95 |
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Factory Sealed Allen Bradley AB 1756 M02AE Ser A Servo Module $1,200.00 |
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ALLEN BRADLEY 808-NLA4 SPEED SWITCH SER F NNB $910.00 |
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ALLEN BRADLEY 808-G2 SPEED SWITCH SER E NIB $800.00 |
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Allen Bradley 1494V-DS100 Ser A Disconnect Switch 100AMP 600VAC $749.99 |
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ALLEN BRADLEY 350-BAV REVERSING DRUM SWITCH SZ 1 SER. B NEW NIB $649.00 |
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Square D Nema 4 contact 8502SF02S Ser A $649.99 |
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ALLEN BRADLEY 808-M1 SPEED SWITCH SER F 5A 600V NNB $635.00 |
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NIB ALLEN BRADLEY 837-H3A TEMPERTURE SWITCH SER A $600.00 |
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Allen Bradley 1494V-DS400 SER A $592.49 |
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1756-PLS Ser/B Allen Bradley ControlLogix Prog Limit Switch W/ Resolver TESTED $589.95 |
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NEW ALLEN BRADLEY 1494V-DRL644 DISCONNECT SWITCH SER. A $500.00 |
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NEW ALLEN BRADLEY 1494V-DRL622 DISCONNECT SWITCH SER. B $500.00 |
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NEW ALLEN-BRADLEY 803S-BCZ33K PROGRAMMABLE LIMIT SWITCH SW 803S SER. A C-4180 $495.00 |
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Allen Bradley 1494V-DS400 Ser A Disconnect Switch $500.00 |
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ALLEN BRADLEY 1494M-NF100 REMOTE OPERATED 100 AMP DISCONNECT SWITCH SER A NNB $499.99 |
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Square D I-Line Busway Switch PQ-3620 PQ3620 Ser:3 200A 200 Amp 3P3W 600V used $375.00 |
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Square D I-Line Busway Switch PQ-3620 W PQ3620W Ser:3 200A 200 Amp 3P3W 600V $375.00 |
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NIB ALLEN BRADLEY 801-ASN21X LIMIT SWITCH SER A $470.00 |
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H362AWK SQUARE D HEAVY DUTY DISCONNECT SWITCH SER. F05 60 AMP – NEW – 1 YR WARR $400.00 |
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Square D I Line Busway Unit Fusible Busplug PQ4210G 100A 3P4W 240V 100 Amp Ser:4 $350.00 |
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ALLEN BRADLEY 800H-4HX7 SER. N NEW HAZARDOUS LOCATION HEAVY DUTY SWITCH 800H4HX7 $375.00 |
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A-B Allen Bradley 840-D1 Ser A Float Switch Style D NEW $369.99 |
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Square D 9012 GCW-23 Ser C Pressure Control Switch NEW $349.99 |
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NIB AB Allen Bradley 836-C1A SER A Pressure Control $350.00 |
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NIB AB Allen Bradley 1494R-N30 Ser A Disconnect Switch Rod Operated 30 AMP $350.00 |
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ALLEN BRADLEY 1494R-N30 SER. A NEW DISCONNECT SWITCH 1494RN30 $350.00 |
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ALLEN BRADLEY 808-J1 SPEED SWITCH SER F $350.00 |
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SQUARE D HEAVY DUTY SAFETY SWITCH HU362 SER. F05 FACTORY SEALED HU362 $325.00 |
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Square D 9012 GCW-23 Ser C Pressure Control Switch NEW $329.99 |
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HP VXI 75000 SER C 64 CH FORM C SWITCH E1442A w/ TERM BLOCK, MANUAL & DRIVERS $324.99 |
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ALLEN BRADLEY LIMIT SWITCH 801-DMC21 SER. A NEW 801DMC21 $325.00 |
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ALLEN BRADLEY1791-N4C2 SER.A FACTORY SEAL $319.99 |
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NEW ALLEN BRADLEY 1494V-DRL611 DISCONNECT SWITCH SER. B $300.00 |
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Allen Bradley 802T-HD OilTight Limit Switch Ser C *NIB* $299.00 |
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ELECON INST 1034-H-0-0242-AA SER 1000 CURRENT REPEATER $299.00 |
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MAGNETEK GEMCO SER. 2000 ROTARY LIMIT SWITCH 2000-2904 RATIO 1:1 S70 CAMS $299.95 |
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NEW SQUARE D LIMIT SWITCH 10 AMP SER. D MODEL 9007AW18 $299.00 |
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NEW SQUARE D LIMIT SWITCH 10 AMP SER. C MODEL 9007AW18 $299.00 |
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ALLEN BRADLEY CAT 1494V-DS200 SER B DISCONNECT SWITCH – USED $300.00 |
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ALLEN BRADLEY 1494V-W11 1494VW11 SER. A OPERATING HANDLE – NEW – 1 YR WARRANTY $300.00 |
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ALLEN BRADLEY 1494V-DS400 LINE TERMINAL GUARD SER A $299.00 |
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SQUARE D HEAVY DUTY SAFETY SWITCH H-321-N SER. E2 FACTORY SEALED H321N $275.00 |
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ALLEN BRADLEY DISCONNECT SWITCH 1494F-NF30 SER. A FACTORY SEALED 1494FNF30 $275.00 |
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SQUARE D INDUSTRIAL PRESSURE SWITCH 9012 GDW-1 SER. C NEW 9012GDW1 $275.00 |
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ALLEN-BRADLEY 440G-S36047 SPARTAN GUARD LOCKING INTERLOCK SWITCH SER.A QUANTITY! $249.99 |
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SQUARE D 9012 GCW-2 Ser.A MANOSTAT PRESSURE SWITCH $224.99 |
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A-B 1494V-DS100 FUSE DISCONNECT SWITCH KIT SER.B WITH $249.99 |
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ALLEN-BRADLEY 2755-NP1 BUL. 2755 RETROREFLECTIVE PHOTOELECTRIC SWITCH SER. A $234.99 |
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ALLEN BRADLEY FUSIBLE DISCONNECT 1994V-DR666 SER 1 NEW $250.00 |
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ALLEN BRADLEY 800H-FPX6D 2 POSITION PUSH-PULL RED CAP TYPE 7 & 9 SER.C NEW!! $229.99 |
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ALLEN BRADLEY 440E-L22BNSL SER A NNB $253.00 |
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Allen Bradley 808-R1 Ser. F Speed Switch *NEW* $250.00 |
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A-B Allen Bradley 836T-T252JX23X9 Pressure Switch Ser A $249.99 |
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Allen Bradley 802T-NX29 Limit Switch Ser 1 40192-021-56 $255.00 |
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ALLEN BRADLEY 836-C1 SER A PRESSURE CONTROL SWITCH NNB $240.00 |
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Square D 9012 GCW-3 Ser. C Pressure Switch Interruptor $225.00 |
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Square D 9012 GCW-23 Ser C Pressure Control Switch $229.99 |
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2 USED SQUARE D 100 AMP 240 VOLT 3 POLE SER FO3 WITH FUSES (FRN-R-100) $200.00 |
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Allen Bradley Pressure Switch # 836T-T252JX20 Ser A NIB $225.00 |
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SQUARE D INDUSTRIAL PRESSURE SWITCH 9012 GAW-4 SER. C NEW SEALED 9012GAW4 $225.00 |
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ALLEN-BRADLEY 800P-F2CB SER.E NEW! PALM OPERATED PUSH BUTTON $199.99 |
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Square D 9012 GCW-22 Ser B Pressure Control Switch $219.99 |
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SQUARE D AW18 SER. D PRECISION LIMIT / POSITION SWITCH 2-POLE 10A 600V – NEW $222.00 |
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Square D PS-3606 60 Amp I-Line Busway Switch Bus Plug 600 V 3 Phase 3 Wire Ser 1 $200.00 |
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HP VXI 75000 SER C 32 CHAN MERCURY WETTED SWITCH Z2417A $199.99 |
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Allen-Bradley 800P-S1CG1B Ser D 800PS1CG1 Push Button $200.00 |
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ALLEN BRADLEY 802T-HT SER. 1 NEW LIMIT SWITCH 802THT $195.00 |
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NIB MICRO SWITCH LOGIC MODULE MODEL TR3-4 SER.NO. 3F5175, 15 VAC (BIN 69) $200.00 |
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SQUARE D PRESSURE SWITCH GBW-1 GBW1 SER C NIB $185.00 |
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BRAND NEW Allen Bradley 609-AJW Manual Starting Switch NEMA 12 ENC 3 Phase Ser K $200.00 |
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ALLEN BRADLEY 802MC-AY60 ser D XY60 ser.B LIMIT SWITCH $150.00 |
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SQUARE D 9007-C86L REED SWITCH 9007C86L SER. A NIB $200.00 |
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ALLEN BRADLEY 849A-ZOD24 SER.B TIME DELAY W/ AB 79A86 COIL $200.00 |
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SQUARE D FUSED SAFETY SWITCH 3R SER.F06 CAT#H22/NDS $199.99 |
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Square D QMB-361-T Ser D2 30 amp 3 pole 600 Vac Fused Branch Switch Panel Mount $199.99 |
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SQUARE D FOOT SWITCH W/ GUARD 9002 AW-2 SER. C NEW 9002AW2 $180.00 |
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Squrare D 400Amp LAL36400 Ser 4 3Pole Circuit Breaker $198.00 |
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Allen Bradley 836T-T253J Ser A Pressure Control $185.00 |
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Square D I-Line PQ3603G Ser. 4 Busway Switch 30Amp. 600V 3Pole w/ Enclosure $194.99 |
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Square D PQ3603G Ser. 4 Busway Switch 30Amp. 600V (S39i) $179.99 |
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SQUARE D HEAVY DUTY SAFETY SWITCH H-361 SER. E1 NEW H361 $175.00 |
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SQUARE D PRESSURE SWITCH 9012 GAW-1 SER. C NEW 9012GAW1 $175.00 |
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ALLEN BRADLEY 800T-T4R4AAAA NEMA TYPE 4,13 TOGGLE SWITCH 4 WAY SER T NNB $179.99 |
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Telemecanique L143-2GF SER F 9949 Limit Switch A600 $185.98 |
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Telemecanique L144-2GF SER F Limit Switch Lox Switch $185.98 |
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Square D pressure switch 9012 GHW-1 ser C (2636) $169.99 |
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SQUARE D 9007 TUD-5 SER B LIMIT SWITCH $169.99 |
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Square D PQ3603 Ser. 1 Busway Switch 60Amp. 600V (S39J) $159.99 |
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ALLEN BRADLEY 802M-AMY16 SER B LIMIT SWITCH PRE-WR NNB $168.00 |
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Allen Bradley 802T-AMT Ser 2 LIMIT SWITCH 600VAC 10AMP $176.24 |
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Allen Bradley 800MR-J631BBK Selector Switch Ser C NEW $175.00 |
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Square D Motor Starting Switch 2510 KW2 0626 Ser B New $175.00 |
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SQUARE D 9007-BR53D LIMIT SWITCH 9007BR53D SER. A $175.00 |
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Square D 9001 K2L1R21H13 Red Pushbutton Switch 110-120V 50/60Hz KM1 Ser G New $174.95 |
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ALLEN-BRADLEY 802PR-LBAJ1 INDUCTIVE PROXIMITY SENSOR SER. E 20-250V AC/DC USED** $165.00 |
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NEW ALLEN-BRADLEY SELF-CONTAINED SIDE SENSING PROXIMITY SWITCH 802PR-LBAB1 SER.E $159.95 |
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Allen Bradley 45MLD-8LEA1-P4 SER A $167.99 |
Switch Ser Questions
Protein Phosphorylation Related Peptides
Definition
Protein phosphorylation is a post-translational modification of proteins in which a serine, a threonine or a tyrosine residue is phosphorylated by a protein kinase with the addition of a covalently bound phosphate group. There are several protein phosphorylation related peptides that belongs to regulatory domain of kinases used for studying the physiological role of enzymes.
Discovery
In 1906, Phoebus A. Levene at the Rockefeller Institute identified phosphate in the protein Vitellin 1. In 1954, phosphorylation of a protein was observed when a liver enzyme catalyzed the phosphorylation of casein and became known as a protein kinase 2. A year later, the role of phosphorylation became more interesting as Fischer and Krebs, and Wosilait and Sutherland 3, showed that an enzyme involved in glycogen metabolism was regulated by the addition or removal of a phosphate, suggesting that reversible phosphorylation could control enzyme activity. A peptide fragment of the thyroid hormone (TR)-binding protein (TRBP), the LXXLL motif, phosphorylated on Ser884 important for receptor selectivity and LXXLL-binding affinity correlates with TRBP transcriptional activity 4. Aquaporin – 2 (254 – 267), pSER256, human, a peptide fragment of the human aquaporin-2 (AQP2) phosphorylated at Ser256, plays a key role in vasopressin signaling in the renal-collecting duct 5.
Structural Characteristics
Phosphorylation refers to the addition of a phosphate to one of the amino acid side chains of a protein. Phosphates are negatively charged so that their addition to a protein leads to conformational change of the protein. Many bacterial species express ‘eukaryotic-like’ Ser/Thr or Tyr protein kinases and phosphatases that are candidate mediators of developmental changes and host/pathogen interactions. Studies reveal that universal mechanisms of regulation and substrate recognition govern the functions of prokaryotic and eukaryotic Ser/Thr protein kinases (STPKs). Several structures also support novel mechanisms of regulation, including dimerization of STPKs, metal-ion binding and substrate mimicry 6. There are several small peptides are involved in regulation of protein phosphorylation. Sequence of [pSer884] Thyroid Hormone Binding Protein (TRBP), biotin labeled is BIOTIN-KDVTLT(pSer)PLLVNLLQSDIS 4. Aquaporin – 2 (254 – 267), pSER256, human sequence is RQ-pS-VELHSPQSLPR. These peptides are used for thyroid hormone and vasopressin-dependent trafficking studies respectively 5.
Mode of Action
The transfer of phosphates onto proteins is catalyzed by a variety of protein kinases in the cell. The hydroxyl groups (-OH) of serine, threonine, tyrosine or histidine amino acid side chains are commonly used for addition of phosphate group. A second class of enzymes, phosphatases, are responsible for the reverse reaction, in which phosphates are removed from a protein. Some of these enzymes are extremely specific, potentially phosphorylating or dephosphorylating only a few target proteins, while others are able to act broadly on many proteins. The examples of known targets of phosphorylation include most protein components of the cell, including enzymes, structural proteins, cell receptors, ion channels and signaling molecules. If a protein is controlled by its phosphorylation state, its activity at any one time will be directly dependent on the activity of the kinases and phosphatases that act on it. It is quite common for a phosphate group to be added or removed from a protein continually, a cycle that allows a protein to switch rapidly from one state to another 7. [pSer884] Thyroid Hormone Binding Protein (TRBP) peptide interacts with nuclear receptors. Ligand-dependent interaction of nuclear receptors and co-activators is a critical step in nuclear receptor-mediated transcriptional regulation. Serine884 of TRBP LXXLL motif is a key residue for receptor selectivity 4. Aquaporins form pores in the membranes of cells and selectively pass water molecules through the membrane, and prevent the crossing of sodium, potassium and other ions and small molecules. Human aquaporin-2 (AQP2) peptide AQP2 residues including S256 and S261, are altered in response to vasopressin. In the presence of vasopressin, AQP2 monophosphorylated at Ser256 and diphosphorylated AQP2 (pSer256/261) increase in abundance, whereas AQP2 monophosphorylated at Ser261 decreases, suggesting that both sites are involved in vasopressin-dependent AQP2 trafficking 5.
Functions
Regulate cell processes, through the use of phosphorylation cycles and cascades, the cell is able to regulate a diverse set of processes, including cellular movement, reproduction and metabolism. It is the simplicity, reversibility and flexibility of phosphorylation that explains why it has been adopted as the most general control mechanism of the cell.
Signalling networks, the study of phosphorylated proteins combined with mass spectrometry have been used to identify and quantify dynamic changes in phosphorylated proteins over time. Systematic analysis of complex phosphorylation networks has helped in understanding of cellular processes8.
PKC, C2 Domain (49 – 53), This peptide belongs to the C2 regulatory domain of e-protein kinase C, also known as e-PKC/V1. This peptide, used in studying the physiological role of isozymes, is most likely the PKC-selective activator and is found to be cardioprotective 9.
Regulatory functions, several enzymes and receptors are switched “on” or “off” by phosphorylation and dephosphorylation. Reversible phosphorylation results in a conformational change in the structure of enzymes and receptors, causing them to become activated or deactivated. Many phosphorylation related peptides act as a modulator of enzyme function 10.
About the Author
Bio-Synthesis Inc. a leading provider for Custom Antibody, Custom Peptide Synthesis, Custom siRNA Synthesis, Organic Laboratory Technique, Antibiotic Peptides.
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